Pre-Conference Workshop Day

Tuesday September 12, 2023

8:30 am Workshop A: Overviewing Fundamentals of LNP Structure to Relay into Analytical

Synopsis

  • Reviewing the basic structure of LNPs and key considerations in its formulation 
  • Translating structural properties to function as a delivery vehicle 
  • Reflecting on the LNP delivery journey and the analytical bottlenecks throughout 

10:30 am Morning Refreshments & Networking

11:00 am Workshop B: Building Experimental & Quantitative Analytical Platforms to Inform the Translational Gap from Bench to Bed

Synopsis

  • Design of experimental study to reveal the difference of dosing materials across different species
  • Model-informed drug development – where are we for LNP-mRNA?
  • Integrating the mathematical modelling to accelerate the translational journey of LNP

1:00 pm Lunch and Networking

2:00 pm Workshop C: Utilizing Advanced Methods to Characterize LNP Heterogeneity and Encapsaultion

  • Sherry Zhu Director - Chemistry Manufacturing & Controls Team Lead, Bristol Myers Squibb
  • Jiawei Gong Senior Scientist, Bristol Myers Squibb

Synopsis

  • Overview of LNP Quality Attributes 
  • Strategies for platforming methods and challenges
  • Introduction of advanced tools to characterize heterogeneity, structure and encapsulation