Yun Zhu
Seminars
Thursday 19th November 2026
Systematic Evaluation of RiboGreen-Based Encapsulation Efficiency Measurements for Lipid Nanoparticles
12:10 pm
- Evaluate total and free RNA assays to identify root causes of variability in EE% measurement
- Identify that nanoparticle-mediated fluorescence attenuation results in free assay imprecision
- Demonstrate that matrix-matched calibration restores EE% accuracy in both LNP and targeted LNP
