Ghloan-Martin Hamraz

Ex-BioNTech, BioNTech

I am an R&D formulation scientist with 9+ years of experience in nanomedicine, specializing in lipid nanoparticles (LNPs), liposomes, and polymer-based RNA delivery systems. During my PhD at BioNTech, I pioneered a patented PEG-free LNP platform to circumvent PEG-related liabilities. My work bridges particle engineering, high-throughput screening, and in vivo biodistribution studies to drive next-generation non-viral drug delivery solutions. I am passionate about translating scientific innovation into scalable technologies that expand the therapeutic potential of RNA medicines.

Seminars

Wednesday 18th November 2026

Advanced Surface & Tissue Analytics for Triphosphate Stabilized PEGFree LNPs

2:40 pm

Demonstrate that removing PEG-lipid from a four-component LNP system does not compromise colloidal stability, RNA integrity over nine months, or in vivo hepatic potency, provided surface charge is controlled through polyanion binding
Microscale thermophoresis (MST) was originally developed for fluorescence-labelled protein binding and here adapted to directly quantify small-molecule ion binding to LNP surfaces, establishing anion–lipid affinity as a measurable parameter
Deploy MALDI-MS imaging to spatially resolve ionizable lipid distribution across hepatic microanatomy at 20 μm resolution, linking formulation to intrahepatic biodistribution patterns