Elias Halabi
Seminars
Wednesday 19th November 2025
Panel Discussion: Decoding LNP Function Through Advanced Imaging to Enhance Therapeutic Design & Endosomal Escape
11:40 am
- What kind of technology is used for LNP imaging?
- How to analyze the images and generate robust, reliable conclusions?
- How to translate from the images to animal models, in vitro/in vivo correlation?
Wednesday 19th November 2025
Optimizing Dual-Cargo Delivery: Advanced Characterization Techniques for Gene Editing with Lipid Nanoparticles
1:55 pm
- Lipid nanoparticle-based gene therapies require the delivery of multiple nucleic acid cargoes (e.g., Cas9 mRNA and guide RNA). The identification of the optimal ratio of mRNA to guide RNA will be discussed
- New advanced characterization strategies to quantify dual-cargo encapsulation via direct injection using SEC-HPLC will be proposed for routine analysis
- Orthogonal methods for assessing LNP packing and morphology, as well as their correlation to in vivo activity, will be examined
NEW DATA
