Using High-Resolution Mass Spectrometry to Characterize Next- Generation Targeted LNPs
- Apply high-resolution mass spectrometry to simultaneously characterize lipid, RNA, antibody, and conjugate components within targeted LNP systems
- Quantify conjugation efficiency, assess conjugation site specificity, and investigate product-related heterogeneity impacting therapeutic performance
- Establish comprehensive analytical workflows to support discovery, process development, and CMC readiness for targeted LNP therapeutics