LNP Characterization: From pDNA, mRNA & tLNP Purity to In-Process Control

9:30 am - Thursday 19th November 2026

A typical tLNP production process involves mixing nucleic acid(s) with selected lipids, attaching a targeting ligand(s), then purifying and formulating the particles
When multiple payloads and multiple ligands are used, tLNP formulations typically yield heterogeneous particles containing more than 90% impurities
To better understand these processes and support improved (t)LNP design, new analytical methods and systems have been developed. This presentation will introduce 2D LC switcher analytics
The reliability of analytical methods, including the impact of surface effects, will also be discussed