Advanced Chromatography Analytics for Next-Generation LNP-Based Biopharmaceuticals
Time: 9:30 am
day: Conference Day Two
Details:
- The presentation introduces innovative chromatographic techniques that use Convective Interaction Media (CIM) monolithic columns for detailed analysis of various LNP formulations like CAR-T cell therapies, CRISPR gene editing, and combination vaccines
- The highlighted approach is an advanced 2D chromatography platform that enables characterization of various LNP-based therapeutics, including assessments of quality attributes such as encapsulation efficiency, RNA integrity, and the detection of nucleic-acid lipid impurities
- Additionally, an analysis of coated LNP formulations is shown to assess ligand density
